A pharmaceutical composition for treating a cancerous kidney tumor expressing a Tumor-associated Antigenic Target 184 (TAT 184) polypeptide of Figure 2 which comprises an effective amount of an anti-Tumor-associated Antigenic Target 184 (TAT 184) antibody or fragment thereof that specifically binds the TAT 184 polypeptide of Figure 2 in admixture with a pharmaceutically acceptable carrier, wherein said antibody or antibody fragment is conjugated to a growth inhibitory agent or cytotoxic agent.ĥ. An anti-Tumor-associated Antigenic Target 184 (TAT 184) antibody or fragment thereof that specifically binds the TAT184 polypeptide of Figure 2, for use in the prevention or treatment of a kidney proliferative disorder associated with increased expression or activity of said TAT 184 polypeptide, wherein said antibody or antibody fragment is conjugated to a growth inhibitory agent or cytotoxic agent.Ĥ.
An anti-Tumor-associated Antigenic Target 184 (TAT 184) antibody or fragment thereof that specifically binds the TAT184 polypeptide of Figure 2, for use in the treatment of a cancerous kidney tumor comprising cells that express said TAT polypeptide in a mammal, wherein said antibody or antibody fragment is conjugated to a growth inhibitory agent or cytotoxic agent.ģ.
An anti-Tumor-associated Antigenic Target 184 (TAT 184) antibody or fragment thereof that specifically binds the TAT184 polypeptide of Figure 2, for use in inhibiting the growth of a kidney tumor cell expressing said TAT 184 polypeptide, wherein said antibody or antibody fragment is conjugated to a growth inhibitory agent or cytotoxic agent.Ģ. JOHN F HARMS ET AL: "KISS1 metastasis suppression and emergent pathways" CLINICAL & EXPERIMENTAL METASTASIS OFFICIAL JOURNAL OF THEMETASTASIS RESEARCH SOCIETY, KLUWER ACADEMIC PUBLISHERS, DO, vol. STEEG P S ET AL: "METASTASIS SUPPRESSOR GENES: BASIC BIOLOGY AND POTENTIAL CLINICAL USE" CLINICAL BREAST CANCER, CIG MEDIA GROUP, LP, US, vol. Genetic regulation of human breast carcinoma metastasis" BREAST CANCER RESEARCH, CURRENT SCIENCE, LONDON, GB, vol. WELCH D R ET AL: "Molecular biology of breast cancer metastasis. KOTANI M ET AL: "The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54" JOURNAL OF BIOLOGICAL CHEMISTRY.(MICROFILMS), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol.
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